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KMID : 0387820220290020044
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Clinical Pediatric Hematology-Oncology
2022 Volume.29 No. 2 p.44 ~ p.51
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IVIG Treatment Response and Age are Important for the Prognosis of Pediatric Immune Thrombocytopenia
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Sakong Min-Gi
Prk Ji-Hoon
Son Sang-Beom
Kim Yu-Kyung
Lee Jae-Min
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Abstract
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Background: This study aimed to identify chronicity predictors of pediatric primary immune thrombocytopenia (ITP).
Methods: This study retrospectively reviewed the medical records of patients with pri-mary pediatric ITP admitted to a tertiary medical center between 2010 and 2021. Forty-five patients with a platelet count ＜20,000/μL at the time of diagnosis who were treated with intravenous immunoglobulin (IVIG) were enrolled in this study.
Results: According to the disease phase, 28, 6, and 11 patients were classified into the newly diagnosed (ND), persistent, and chronic groups, respectively. The number of patients over 6 years of age was significantly higher in the chronic group than in the ND and persistent groups. After 14 days of IVIG treatment, more patients had a complete response in the non-chronic groups than in the chronic group. In uni-variate analysis of risk factor for chronic ITP, age 6 years or older and IVIG dose ＜2 g/kg were found to be risk factors for chronic ITP, and these two factors were also confirmed as significant risk factors in multivariate analysis.
Conclusion: In conclusion, in our study, patients over 6 years of age, and those who received IVIG doses less than 2 g/kg were more likely to progress to chronic ITP.
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KEYWORD
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Immune thrombocytopenia, Chronic ITP, Predictive factor, Children
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